The University of North Carolina at Chapel Hill;The University of Chicago
发明人:
Wenbin Lin,Chunbai He,Demin Liu
申请号：
US15034799
公开号：
US10517822B2
申请日:
2014.11.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Nanoscale coordination polymer nanoparticles for the co-delivery of multiple therapeutic agents are described. The multiple therapeutic agents can include a combination of different chemotherapeutic agents, a combination of one or more chemotherapeutic agents and one or more nucleic acids, such as small interfering RNA (siRNA) or microRNA, a combination of one or more chemotherapeutic agents and a photosensitizer (i.e., for use in photodynamic therapy), or a plurality of different siRNAs. Pharmaceutical formulations including the nanoparticles, methods of using the nanoparticles to treat cancer, and methods of making the nanoparticles are also described.
