Multilayer, active substance-containing transdermal therapeutic system (TTS) for releasing active substances via the skin to the human body.A disadvantage of known transdermal therapeutic systems is that, due to insufficient cohesion, they are prone to smear during application on the skin and therefore do not reliably adhere to the skin.To improve cohesion, a TTS (10) comprises two or more self-adhesive adhesive layers (1, 3, 3′, 3″) and at least one non-self-adhesive, high-tensile-strength and active substance-permeable intermediate layer (2, 2′, 2″)； the said adhesive layers and intermediate layer(s) are alternately arranged and joined to one another.The multilayer TTS is suited for the administration of pharmaceutical active substances via the skin for therapeutic purposes.
