This invention relates to an improved method and apparatus for generating profiled pulses of ultrasonic frequency vibratory energy at a distal surface of an ultrasonic applicator of an ultrasonic surgical instrument for application to tissues of a patient, including the providing of a profiled pulse signal with a first profile and a maximum magnitude during a first time portion and a second profile and a minimum magnitude during a second time portion, the second time portion being greater than or equal to the duration of the first time portion, the first time portion being between one millisecond and fifty milliseconds in duration, and the maximum magnitude in the range between two and twenty times the minimum magnitude.
