UNIAO BRASILEIRA DE EDUCACAO E ASSISTENCIA MANTENEDORA DA PUCRS;UNIÃO BRASILEIRA DE EDUCAÇAO E ASSISTÊNCIA- MANTENEDORA DA PUCRS
发明人:
申请号：
EP13867908.9
公开号：
EP2940040B1
申请日:
2013.12.27
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention provides the use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. Also disclosed are: a gene construct for the expression of said binder； a production process； a process of evaluation of tumor cells； and a method of sensitization of tumors to chemotherapeutic agents. The invention also provides a new experimental model in vivo and in vitro for the development/evaluation of anti-tumor agents. The pharmaceutical compositions of the invention provide anti-tumor action and have high specificity to neoplastic cells, resulting in less cytotoxicity to normal dividing cells. These and other advantages of the invention are characterized as a solution to the drawbacks of currently known chemotherapy therapeutic regimens.
