The present invention provides a use of Manilkara zapota extracts in a composition for regulating the gene expression of NOS, EDN, IL, VCAM, CASP, PDGF, FGF, IGF2BP3, IGF1R, Coagulation factor and SERPINE. Manilkara zapota extracts can effectively improve the regulation of blood pressure, reduce the inflammation of blood vessels, reduce the proliferation of blood vessels, and prevent the formation of blood clots, so as to achieve the effect of cardiovascular care. The Manilkara zapota extracts is prepared by extracting Manilkara zapota using water, alcohols, or mixtures of water and alcohols as solvents.本發明提供一種人心果萃取物用於調控NOS基因、EDN基因、IL基因、VCAM基因、CASP基因、PDGF基因、FGF基因、IGF2BP3基因、IGF1R基因、凝血因子基因、及SERPINE基因表現量之組合物的用途，能有效改善血壓的調控、降低血管的發炎、減少血管的增生、及預防血栓的形成，以達到心血管保健之功效。其中該人心果萃取物，係人心果以水、醇、或醇水混合物之溶劑所萃取而得。
