An interluminal medical treatment device configured to treat a targeted treatment site within a body lumen. The interluminal medical treatment device can include an elongated generally tubular outer member. The outer member can include an expandable distal portion, an expandable proximal portion, and a central portion of limited expandability. The interluminal medical treatment device can include at least one membrane. The outer member and at least one membrane may define a housing area positioned between the proximal portion and distal portion of the outer member. The outer member and at least one membrane can be configured to redirect fluid flow within a body lumen away from the housing area inner member or inner passageway.
