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Single-stranded nucleic acid molecule for gene expression control with delivery function
专利权人:
株式会社ボナック
发明人:
大木 忠明,青木 絵里子,江村 智佐登,濱崎 智洋
申请号:
JP2017076271
公开号:
JP6585116B2
申请日:
2017.04.06
申请国别(地区):
JP
年份:
2019
代理人:
摘要:
Provided is a single-stranded nucleic acid capable of inhibiting expression of a target gene having a delivery function. A molecule containing, from the 5'-side to the 3'-side, a 5'-side region (Xc), a linker region (Lx), an inner region (Z), a linker region (Ly) and a 3'-side region (Yc) in this order, wherein the aforementioned inner region (Z) is constituted by linkage of the inner 5'-side region (X) and the inner 3'-side region (Y), the aforementioned 5'-side region (Xc) is complementary to the aforementioned inner 5'-side region (X), the aforementioned 3'-side region (Yc) is complementary to the aforementioned inner 3'-side region (Y), at least one of the aforementioned inner region (Z), the aforementioned 5'-side region (Xc) and the aforementioned 3'-side region (Yc) comprises an expression inhibitory sequence that inhibits expression of a target gene, and at least one selected from the group consisting of the 5'-terminus, the 3'-terminus, the aforementioned linker region (Lx) and the aforementioned linker region (Ly) is bound to a bio-related substance.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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