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SEAMLESS CAPSULE COMPRISING GELATIN AND A PLASTICIZER
专利权人:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
发明人:
UCHIYAMA, YOSHIHIRO,YOSHINARI, TOMOHIRO
申请号:
NZ58257608
公开号:
NZ582576A
申请日:
2008.06.27
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a method of producing a seamless capsule comprising a shell formed by a shell composition comprising gelatin and a plasticizer, the shell composition does not comprise an interfacial tension modifier that is a substance that changes the tension produced in the oil-water interface between the capsule content and the aqueous shell composition solution and a gelling agent, and a capsule content without comprising an interfacial tension modifier and a gelling agent by a drip in oil method, wherein temperatures of the capsule content without comprising an interfacial tension modifier and a gelling agent, the aqueous shell composition solution formed by a shell composition comprising gelatin and a plasticizer, the shell composition does not comprise an interfacial tension modifier and a gelling agent and the carrier liquid that is one or more oily substrates selected from medium-chain triglyceride (MCT) oil, olive oil, soybean oil, and corn oil are each controlled near multiple nozzles of an apparatus used for the drop in oil method, wherein the temperature of the capsule content without comprising an interfacial tension modifier and a gelling agent is controlled to a value set ± 2 degrees C within the range of 5 degrees C - 25 degrees C, wherein the temperature of the aqueous shell composition solution formed by a shell composition comprising gelatin and a plasticizer, which does not comprise an interfacial tension modifier and a gelling agent is controlled to a value set ± 2 degrees C within the range of 50 degrees C - 80 degrees C, wherein the temperature of the carrier liquid is controlled to a value set ± 1 degrees C within the range of 1 degrees C - 15 degrees C, wherein a difference between the temperature of the capsule content without comprising an interfacial tension modifier and a gelling agent and the temperature of the aqueous shell composition solution formed by a shell composition comprising gelatin and a plasticizer, which does not comprise an
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