Young Min Kim,Seung Jung Han,Tae Gwon Oh,Sae Woong Park,Sang Nae Cho,Mi Young Hahn,Jee Hee Suh,Kyu Yang Yi
申请号：
US14382548
公开号：
US09364468B2
申请日:
2013.02.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, comprising: (a) a pharmaceutically effective amount of a compound represented by the following chemical formula 1 and (b) a pharmaceutically acceptable carrier. Chemical formula 1 The compound contained as an active ingredient of the present invention inhibits the expression and activity of CO-DH in tubercle bacillus so as to effectively block the detoxification of carbon monoxide, which is an important survival factor of tubercle bacillus, and is safe for the human body since the compound targets CO-DH which does not exist in the human body. In addition, the compound creates a synergistic effect when combined with a conventional tuberculostatic drug, and thus can be more effective for treating tuberculosis.
