PROBLEM TO BE SOLVED: To provide a solution which contains ascorbic acid (including an ascorbic acid derivative) in a stable state even when its content exceeds 15 wt.%, and is further safe even when being applied to a skin.SOLUTION: In a state where the inside of a mixed liquid containing, by weight, 10 to 20% water, 45 to 55% ethoxydiglycol and 20 to 30% propylene glycol, respectively is held to 60 to 80°C (preferably, 70°C), &ge15% ascorbic acid and, when necessary, an additive (such as vitamin B and an ascorbic acid derivative) are added thereto, stirring is performed, and, after the ascorbic acid and additive are dissolved, cooling is performed to obtain a desired solution.COPYRIGHT: (C)2012,JPO&INPIT【課題】15重量%を超えても安定した状態でアスコルビン酸(アスコルビン酸誘導体を含む)を含有し、さらに皮膚に塗布しても安全な溶液を提供する。【解決手段】10~20重量%の水、45~55重量%のエトキシジグリコール及び20~30重量%のプロピレングリコールをそれぞれ含む混合液中を60~80℃(好ましくは70℃)に保持した状態で、アスコルビン酸15重量%以上と必要に応じ添加物(ビタミンBやアスコルビン酸誘導体など)を加えて撹拌し、アスコルビン酸及び添加物が溶解したのち冷却して所望の溶液を得る。【選択図】図2
