Wherein X, R1, R2, R3, R4, R5, n, R1a, R2a, R3a, R4a, R5a, R6a, R7a, X8, and na are defined herein or the N-oxide derivatives thereof or prodrugs thereof, or a pharmaceutically acceptable salt, solvate or hydrate thereof. The invention further provides combinations of a compound of Formula V or VI with one or more therapeutic agents and pharmaceutical composition thereof.