COMPOSITION CONTENANT SOUS FORME STABLE UNE MOLÉCULE D'ACIDE NUCLÉIQUE SIMPLE BRIN QUI SUPPRIME L'EXPRESSION DU GÈNE TGF-BÉTA1

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专利权人:

BONAC CORPORATION;Takeuchi, Hirofumi

发明人:

申请号：

EP16859995.9

公开号：

EP3369816A1

申请日:

2016.10.28

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention provides a composition containing a single-stranded nucleic acid molecule consisting of a nucleotide sequence shown by 5'-AGCAGAGUACACACAGCAUAUACC-P-GGUAUAUGCUGUGUGUACUCUGCUUC-P-G-3' (SEQ ID NO: 1)(in the sequence, P is a proline derivative linker represented by (I) in the DESCRIPTION) and a buffer, and having the following features:(a) being in the form of a solution at ambient temperature； and(b) a content of the nucleic acid molecule after storage at 25°C, relative humidity 60% for 4 weeks, of not less than 80% relative to the content at the time of start of the storage.

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