Heterocyclic compounds of formula (1), Methods for their preparation, Pharmaceutical compositions containing these compounds and their Therapeutic use.Claim 1: a compound of the formula (1), or Salt, prodrug, a Solvent, a taut u00f3mero a deuterated Analogue, isomer or a pharmaceutically acceptable, where: (i) y u00b2 is n e or C； or (ii) y u00b2 is c or e is n； y u00b9 is CH o n； l is A Link, alquileno c u2081 u208b u2086 option Alquileno eventually replaced, c u2081 u208b u2086 deuterated optionally substituted, - C (r u2076r u2077) -, - C (o) - nr u2079 ch u2082n (r u2079) -, -, -, - so u2082n (r u2079)N - (r u2079) C (o) n (r u2079) - N - (r u2079) SO u2082 -, - N (r u2079) ch u2082 -, - or - alquileno c u2081 u208b u2084 - or - - - - - or alquileno c u2081 u208b u2084, nr u2079c (OR) - N - (SO u2082 r u2079) -, - C (o) - (o) -, - S, - SO u2082 -, - O -, - S -, - P (o) (r u1d43), alquileno c u2082 u208b u2086 optionally replaced,- ch = C (r u1d47) - or - (optionally replaced if r u1d9c) (r u1d9c) optionally substituted； or r u2076 and r u2077 considered jointly with the carbon Atom to which together form a Ring of 3 to 6 members optionally replaced with 0-2 heteroatoms selected from o, N or s or a Oxo is optionally substituted alkyl； r u1d43 c u2081 u208b u2086,Optionally substituted aryl or heteroaryl optionally substituted； r u1d47 is H or alkyl c u2081 u208b u2086； or r u1d47 and r u00b9 considered jointly with the carbon Atom to which together form a ring carboc u00edclico 3 to 6 members or an optionally substituted Heterocyclic Ring of 4 to 8 members You can optionally substituted heteroatoms has between 1 and 2, as members of the ring,Select from o, N or s, where nitrogen Atoms or Sulfur Ring can optionally be oxidized； each r u1d9c considered independently c u2081 u208b u2086 is alkyl or alkoxy c u2081 u208b u2086； r u2079 is H, alkyl or c u2081 u208b u2084 haloalquilo c u2081 u208b u2084； r u00b9, R u00b2, r u2074, r u2076 and r u2077 so N, considering e
