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光熱的に調節される薬剤投与のための感熱性ポリマ/ナノシェル複合体
专利权人:
ウィリアム・マーシュ・ライス・ユニバーシティ
发明人:
ウェスト,ジェニファー,エル,サーシェン,スコット,アール,ハラス,ナンシー,エル,オルデンバーグ,スティーブン,ジェイ,アベリット,リチャード,ディー
申请号:
JP2001510655
公开号:
JP4975919B2
申请日:
2000.07.14
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
A thermally sensitive polymer-particle composite (10) that absorbs electromagnetic radiation, and uses the absorbed energy to trigger the delivery of a chemical (20) is disclosed. Metal nanoshells (16) are nanoparticulate materials that are suitable for use in the present composites (10) and can be made according to a process that includes optically tuning or tailoring their maximum optical absorption to any desired wavelength primarily by altering the ratio or the core diameter to the shell thickness. Preferred nanoshells (16) are selected that strongly absorb light in the near-infrared and thus produce heat. These nanoshells (16) are combined with a temperature-sensitive material (12) to provide an implantable or injectable material for modulated drug (20) delivery via external exposure to near-IR light. This invention provides a means to improve the quality of life for persons requiring multiple injections of a drug, such as diabetes mellitus patients.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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