ZHENG, QIANGANG,XUN, GUOLIANG,XIAO, QITAO,DU-CUNY, LEI
申请号：
ARP180101697
公开号：
AR112168A1
申请日:
2018.06.18
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. Claim 1: a formula compound (1),or a pharmaceutically acceptable salt thereof, wherein: R¹ is selected from: C₁₋₆ alkyl substituted with one or two Rᵃ,C₃₋₆ cycloalkyl substituted with at least one group selected from C₁₋₄ alkyl,haloalkyl C₁₋₄,Halo, oh, CN, - C (o) r, - C (o) o r, - conr832222,-NR-C (O) R -NH-NR’₂,-NR-C (O) OR-Nr-c (o) No. 832222,-OC (O) NR-No. 83228r-So8322； R 'and alternative, substituted by 1 to 2 r74966；a. 7-11 optional member propeller, replaced by one or two r74955；The spiral cells of 7-11 members are composed of 1-2 non atoms selected from nitrogen, oxygen and sulfur. The spiral cells of 7-11 members can be replaced by one or two r74955；With at least one set of selected - nr-c (o) or ',-Nr-c (o) No. 832222,-NR-SO₂R ’,-NR-SO₂OR ’,-NR-SO NR2 -C (O) OH -SO Rand -O₂NR₂,1. Except one or two kinds of r74955 substituted phenyl；The bicyclic heteromorphism consists of one to three heteroatoms selected from nitrogen, oxygen and sulfur. The bicyclic heteromorphism can be replaced by one to two r74955；2-selectively substituting one or two r74955 for pyridan；A 6-member heteromorphism consisting of one to two nitrogen atoms, at least one of which is from - nr-c (o) or ',-Nr-c (o) No. 832222,-NR-SO₂R ’,-NR-SO₂OR ’,-NR-SO₂NR₂,-C (O) OH -SO Rand O₂NR₂,It can also be replaced by up to 3r74955；a Other alternatives (2), replaced by one or two R74966；(3) Option 1 or 2 r74966 replaces the remaining formula；R² is selected from: H, halogen, C₁₋₄-alkyl,haloalkyl C₁₋₄,-C (O) OR y -C (O) NRR³ is selected from: the compounds of the group of formulas (4)；R⁴ is selected from: H, halogen, and Cilo alkyl；R83099 is selected from: H, halogen, c832131 coking plant c83249t；haloalkyl C₁₋₄,and C₃₋₆ cycloalkyl；R⁶ is independently at each occurrence selected from: halogen CN, OH, C₁₋₄ alkyl,C₁₋₄ alkoxy,a. Halogenated tar c831832421；R831111e showed independently in each selected emergence: oxo, halogen, CN, oh, hydrocarbyl c833318324；C₁₋₄ alkoxy,a. Halogenated tar c831832421；U fro
