#$%^&*AU2014268213A120141218.pdf#####ABSTRACT OF THE DISCLOSURE Agonists and antagonists which modulate the activity of TWEAK and TWEAK receptor are provided. The methods, compositions and kits of the 5 invention may be employed in the treatment of disorders such as cancer and immune-related diseases. 10 5995882_1 (GHMatters) P72606.AU.2 LEOWNR