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Agents for magnetic imaging method
专利权人:
Silvio Aime
发明人:
Silvio Aime,Valentina Mainero,Simonetta Chirich Geninatti,Claudia Cabella
申请号:
US12830067
公开号:
US08961927B2
申请日:
2010.07.02
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention provides MRI detectable species of formula (I)Dp-Sn-Nm  (I)whereinD is a MRI detectable moietyS is a spacerN is a molecule of a nutrient or pseudo-nutrientn is 0 or an integerm is an integer andp is an integer.These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors.The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.
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