BANCHEREAU, JACQUES F.,ZURAWSKI, GERARD,FLAMAR, ANNE-LAURE,COBB, AMANDA,MEAD, HOLLY,MONTES, MONICA
申请号：
MYPI 2011000174
公开号：
MY155377A
申请日:
2009.07.16
申请国别(地区):
MY
年份:
2015
代理人:
摘要：
THE PRESENT INVENTION INCLUDES COMPOSITIONS AND METHODS FOR MAKING AND USING A VACCINE THAT INCLUDES A DC-SPECIFIC ANTIBODY OR FRAGMENT THEREOF TO WHICH AN ENGINEERED GAG ANTIGEN IS ATTACHED TO FORM AN ANTIBODY-ANTIGEN COMPLEX, WHEREIN THE GAG ANTIGEN IS LESS SUSCEPTIBLE TO PROTEOLYTIC DEGRADATION BY ELIMINATING ONE OR MORE PROTEOLYTIC SITES OR A DC-SPECIFIC ANTIBODY OR FRAGMENT THEREOF TO WHICH AN ENGINEERED NEF ANTIGEN IS ATTACHED TO FORM AN ANTIBODY-ANTIGEN COMPLEX, WHEREIN THE NEF ANTIGEN COMPRISES ONE OR MORE CODON USAGE OPTIMIZATION THAT INCREASE ANTIBODY-ANTIGEN COMPLEX SECRETION, OR BOTH, WHEREIN THE VACCINE IS ABLE TO ELICIT AN HIV-SPECIFIC T CELL IMMUNE RESPONSE TO GAG P17, GAG P24, NEF AND/OR CYCLIN D1. THE MOST ILLUSTRATING DRAWING IS FIGURE 1.
