Daniel Obrecht,Frank Otto Gombert,Alexander Lederer,Barbara Romagnoli,Christian Bisang
申请号：
US13319052
公开号：
US20120135942A1
申请日:
2009.05.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
β-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Cys4-Xaa5-Xaa6-Xaa7-Xaa8-Arg9-Tyr10-Cys11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with Xaa1, Xaa2, Xaa3, Xaa5, Xaa6, Xaa7, Xaa8, Xaa12, Xaa13, Xaa14, Xaa15 and Xaa16 being amino acid residues of certain types which are defined in the description and the claims, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients or where cancer is mediated or resulting from CXCR4 receptor activity or where immunological diseases are mediated or resulting from CXCR4 receptor activity or for treating immunosuppression or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptides can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
