Compositions and methods for treating and preventing coronary heart disease

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专利权人:

Boston Heart Diagnostics Corporation

发明人:

Ernst J. Schaefer,Eliana Polisecki

申请号：

US14265862

公开号：

US09198890B2

申请日:

2014.04.30

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The invention pertains to a method of determining a statin dosage for an individual in need of treatment with a statin, comprising determining a SLCO1B1 genotype from a nucleic acid sample of the individual, said genotype comprising the presence or absence of the SLCO1B1-056 polymorphism, and determining an ApoE genotype or phenotype identifying an ApoE polymorphism selected from the group consisting of ApoE2, ApoE3, ApoE4, and any combination thereof, wherein the combination of a SLCO1B1 genotype identifying the presence of the SLCO1B1-056 C polymorphism and the ApoE genotype or phenotype identifying one of the ApoE3/4 or ApoE4/4 genotypes indicates the statin dosage.

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