OPTIMIZED MONOCLONAL ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR (TFPI)

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专利权人:

BAYER HEALTHCARE LLC

发明人:

SCHOLZ, PETER,WANG, ZHUOZHI,PAN, JUNLIANG,GRUDZINSKA, JOANNA,VOTSMEIER, CHRISTIAN,TEBBE, JAN,BIRKENFELD, JOERG,WOBST, NINA,BRUECKNER, SIMONE,STEINIG, SUSANNE

申请号：

EP11751244

公开号：

EP2542257A4

申请日:

2011.03.01

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

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