<;P>;PROBLEM TO BE SOLVED: To provide an enzyme-treated royal jelly usable in various applications including cosmetics, and to provide an antioxidant, a moisturizer, a skin fibroblast proliferation promoter, a hypotensive, a fatigue-relieving agent, and a calcium absorption promoter, each containing the same. <;P>;SOLUTION: Provided is an enzyme-treated royal jelly characterized in that it is prepared by adding an extractive solvent, e.g. a hydrous ethanol, to at least one selected from a raw royal jelly and a dried royal jelly, to separate a soluble fraction, and reacting a fraction insoluble to the above extractive solvent with a neutral protease, e.g. thermolysin. <;P>;COPYRIGHT: (C)2009,JPO&INPIT