Administration form (I) comprises a physiologically effective substance (A)； one/more optionally auxiliary materials (B)； synthetic or natural polymer (C)； and optionally natural, semi-synthetic, or synthetic wax (D) (where (I) exhibits a breaking strength of at least 400 N and under physiological conditions the release of (A) is at least partially retarded). An independent claim is included for the preparation of (I). ACTIVITY : Gastrointestinal-Gen； Metabolic； Antianemic； Cardiovascular-Gen； Dermatological； Uropathic； Endocrine-Gen； Cytostatic； Immunomodulator； Muscular-Gen； Osteopathic； Neuroprotective； Antiparasitic； Insecticide； Respiratory-Gen； Anorectic.
