Disclosed herein are centrifuge-free self-contained systems for aseptically separating components of whole blood comprising at least one cassette for receiving whole blood at least one red blood cell exclusion filter at least one leukocyte reduction filters at least one platelet exclusion filter a plurality of product cassettes and optionally a plurality of pumps and valves and wherein the filters, pumps, valves, and cassettes are fluidly connected by tubing and the system does not include a centrifuge. Also disclosed are methods for obtaining blood components using the system.
