REN, PINGDA,LIU, YI,LI, LIANSHENG,CHAN, KATRINA,WILSON, TROY, EDWARD,MARTIN, MICHAEL,ROMMEL, CHRISTIAN
申请号：
NZ59025809
公开号：
NZ590258A
申请日:
2009.07.08
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
Abstract 590258 The present disclosure provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present disclosure are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications. Compounds of the disclosure include: 2-(4-amino-1-(3-hydroxycyclobutyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-7 chloro-1H-indol-5-ol, 2-(4-amino-1-(3-hydroxycyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, 2-(4-amino-1-(3-hydroxycyclobutyl)-1H-pyrazolo [3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, And 2-(4-amino-1-(3-morpholinocyclobutyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
