Herbal MDR for the prevention and treatment of atherosclerosis which includes a summary of the genus Gentiana and a summary of the genus Hippocratea, in particular, gentiana lutea and hippocratea excelsa. Comes as a solid, preferably capsules. Herbal composition is obtained by selecting Rhizome and root of Gentiana luteablending by centrifugation, and separating the supernatant which mingles with the alcoholic extract of Hippocratea excelsa. Applies in the prevention and treatment of atherosclerosis, as well as in atherosclerotic Occlusive disease complications such as blockage of coronary arteries and arteries that supply the heart.