GROGAN, JANE L.,葛洛甘 珍L,葛洛甘 珍L,KIM, JEONG M.,金 琼M,金 瓊M
申请号：
TW104136746
公开号：
TW201628650A
申请日:
2015.11.06
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention describes combination therapy comprising an OX40 binding agonist and an agent that decreases or inhibits TIGIT expression and/or TIGIT activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired, such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.本發明描述包含OX40結合促效劑及减少或抑制TIGIT表現及/或TIGIT活性之藥劑的組合療法及其使用方法,包括對需要增强之免疫原性之病狀進行治療之方法,諸如增加腫瘤免疫原性以便治療癌症或慢性感染。
