A method of manufacturing a bone substitute structure for reconstruction of bone material in a patient, the procedure comprises the steps of: I. providing data reflecting a cavity in a bone of a patient II. define and model a three-dimensional structure that corresponds to the cavity in the bone； and III. provide an individualized bone substitute structure, which corresponds to the defined and modeled three-dimensional structure, in stage II, characterized in that in stage III, the individualized bone substitute structure is provided by combining calcium phosphate cement, growth factors and the patient's own uncoagulated blood, where the individualized bone substitute is obtained using a rapid prototype machine to generate the individualized bone substitute by manufacturing additive layers, where a layer-on-layer sequence of calcium phosphate cement layer, the individualized growth factors and individualized coagulated blood prints the individualized bone substitute structure, and where the rapid prototype machine comprises at least a first printing tube for calcium phosphate, a second printing tube for individualized non-coagulating blood and a third print tube for growth factors, where these at least three printing tubes are computer controlled with respect to the flow rate and the layer-to-layer sequence.Un procedimiento de fabricación de una estructura sustituta del hueso para reconstrucción de material óseo en un paciente, el procedimiento comprende las etapas de: I. proporcionar datos que reflejan una cavidad en un hueso de un paciente II. definir y modelar una estructura tridimensional que corresponde con la cavidad en el hueso； y III. proporcionar una estructura individualizada sustituta del hueso, que se corresponda con la estructura tridimensional definida y modelada, en la etapa II, caracterizado porque en la etapa III, la estructura individualizada sustituta del hueso se proporciona combinando cemento de fosfato de calcio, factores de crecimiento y la pr
