Provided is a chemokine receptor activity regulator, etc. containing as the effective component thereof a pyrazolopyrimidine derivative indicated by formula (I) or a pharmaceutically acceptable salt thereof {in the formula, R1 indicates -NR1aR1b (in the formula, R1a and R1b are the same or different, and indicate a hydrogen atom, an aralkyl, etc.), R2 indicates (II) [in the formula, k and m each indicate an integer between 0 and 2, n indicates an integer between 0 and 2, L indicates a single bond, etc., R5 indicates halogen, etc., R6 indicates aryl, etc., x indicates -CR8 (in the formula, R8 indicates a hydrogen atom, etc.), etc., R7 indicates a hydrogen atom, etc.,] etc., R3 indicates -SO2R13 [in the formula, R13 indicates a lower alkoxy, -NR13d(C=0)R13e (in the formula, R13d indicates a hydrogen atom, etc., R13e indicates a lower alkyl, etc.,) etc.,] and R4 indicates a hydrogen atom, etc.}.本發明提供一種化學激活激素受體活性調節劑等，其含有以式(I)表示之吡唑并嘧啶衍生物或其藥學上所容許之鹽作為有效成分：{式中，R1表示-NR1aR1b(式中，R1a及R1b相同或不同，表示氫原子、芳烷基等)等；R2表示[式中，k及m分別表示0~2之整數，n表示0~2之整數，L表示單鍵等，R5表示鹵素等，R6表示芳基等，X表示-CR8(式中，R8表示氫原子等)等，R7表示氫原子等]等；R3表示-SO2R13[式中，R13表示低級烷氧基、-NR13d(C=O)R13e(式中，R13d表示氫原子等，R13e表示低級烷基等)等]等；R4表示氫原子等}。
