Process for the Preparation of Insulin-Zinc Complexes

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专利权人:

Novo Nordisk A/S

发明人:

Lene Andresen,Rosa Rebecca Erritzoee Hansen,Per Jeppesen

申请号：

US15445305

公开号：

US20170165327A1

申请日:

2017.02.28

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The invention concerns a process for preparing a pharmaceutical formulation comprising an insulin derivative, wherein the process comprises dissolving an insulin derivative in water, adjusting the pH of the solution to a pH above 7.2, adding a zinc solution while stirring continuously and adjusting the pH to the target pH of the formulation.

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