JOAQUIN J. JIMENEZ,JOHN PATRICK MCCOOK,NIVEN RAJIN NARAIN
申请号：
BRPI1007415
公开号：
BRPI1007415A2
申请日:
2010.01.27
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present disclosure relates to the use of vitamin D compounds, such as vitamin D3, or analogs and/or metabolites thereof, to modulate bone marrow progenitors and stromal cells prior to the administration of antineoplastic agents. The methods of the present disclosure may ameliorate myelosuppression by increasing the availability of pluripotent stem cell progenitors, and can be used in combination with standard therapy (e.g. granulocyte stimulating factor) to increase proliferation of myeloid cells and/or improve their mobilization from the bone marrow, thereby diminishing the dose and administration of colony-stimulating factors (CSFs) as well as the recuperation time following chemotherapy.
