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Inhibitors of protein tyrosine kinase activity
专利权人:
METHYLGENE INC.
发明人:
RAEPPEL FRANCK,YUKI YOHEI,ZHAN LIJIE,GAUDETTE FREDERIC,SATO NORIFUMI,VAISBURG ARKADII,MANNION MICHAEL,RAEPPEL STEPHANE,CLARIDGE STEPHEN WILLIAM,KISHIDA MASASHI
申请号:
NZ60295411
公开号:
NZ602954A
申请日:
2011.04.08
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed herein are thieno[3,2-b]pyridine compounds of general formula (I) where the substituents are as defined herein, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are protein tyrosine kinase inhibitors and are intended for use for the treatment of ophthalmic diseases such as chorodial angiogenesis, diabetic retinopathy, age-related macular degeneration or retinal edema. Specific examples of the compounds of formula I include 1-cyclopropyl-3-(3-fluoro-4-(2-(5-((4-(2-(2-(2-methoxyethoxy)ethoxy)acetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea and (S)-1-cyclopropyl-3-(4-(2-(5-((4-(2,3-dihydroxypropanoyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)urea.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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