Provided herein are methods of using compounds and compositions for modulating leukocytic activity, including activity of B cells and/or T cells monocytes, macrophages, and other lymphoid or myeloid-derived cell types, in immune-related diseases or inflammatory diseases. Pharmaceutical compositions and dosing regimens for use in the methods are also provided herein.本文中提供在免疫相關疾病或發炎疾病中使用化合物及組合物調節包括B細胞及/或T細胞、單核細胞、巨噬細胞及其他淋巴或骨髓源細胞類型之活性在內之白血球活性的方法。本文中亦提供用於該等方法中之醫藥組合物及給藥方案。