Yi ZHU,Ole OLSEN,Dong XIA,David JELLYMAN,Katrina BYKOVA,Anne-Marie K. ROUSSEAU,Bill BRADY,Blair RENSHAW,Brian KOVACEVICH,Yu LIANG,Zeren GAO
申请号：
US16615123
公开号：
US20200157224A1
申请日:
2018.06.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure provides a tetra-specific antibody monomer having a N-terminal and a C-terminal, comprising in tandem from the N-terminal to the C-terminal, a first scFv domain at the N-terminal, a second scFv domain, a Fab domain, a Fc domain, and a third scFv at the C-terminal, wherein the first scFv domain, the second scFv domain, the Fab domain, and the third scFv domain each has a binding specificity against a different antigen. In one embodiment, the antigen is a tumor antigen, an immune signaling antigen, or a combination thereof. In one embodiment, the antigen includes CD19, CD3, CD137, 4-1BB, and PD-L1. Multi-specific antibodies comprising the disclosed tetra-specific antibodies are also provided.
