Christin Y. Sander,Joseph B. Mandeville,Bruce R. Rosen
申请号：
US15289036
公开号：
US20170100493A1
申请日:
2016.10.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A method includes administering to a subject (i) a pharmacological agent that binds to receptors in a subject, and (ii) a radiotracer to alter a functional state and occupancy of the receptors in the subject. The method also includes acquiring imaging data of brain tissue in the subject comprising the receptors. The imaging data include positron emission tomography (PET) imaging data and functional magnetic resonance (fMR) imaging data. The method further includes calculating (i) a dynamic response of the functional state to the pharmacological agent and the radiotracer based on the fMR imaging data, and (ii) a dynamic response of the receptor occupancy to the pharmacological agent and the radiotracer based on the PET imaging data.
