SHERMAN, MERRY R.,SAIFER, MARK G. P.,WILLIAMS, L. DAVID,HERSHFIELD, MICHAEL S.,KELLY, SUSAN J.
申请号：
CA2398679
公开号：
CA2398679C
申请日:
2001.02.07
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A naturally occurring or recombinant protein, especially a mutein of porcineurate oxidase (uricase), that is essentially free of large aggregates can berendered substantially non-immunogenic by conjugation with a sufficientlysmall number of strands of polymer such that the bioactivity of the protein isessentially retained in the conjugate. Such conjugates are unusually wellsuited for treatment of chronic conditions because they are less likely toinduce the formation of antibodies and/or accelerated clearance than aresimilar conjugates prepared from protein preparations containing traces oflarge aggregates.
