Steven D. Douglas,Florin Tuluc,Sergurei Spitsin,John Meshki
申请号：
US14888549
公开号：
US20160074428A1
申请日:
2014.05.02
申请国别(地区):
US
年份:
2016
代理人:
摘要：
In accordance with the present invention, a method for inhibiting HIV infection and/or latency in a patient in need thereof is provided. An exemplary method entails administration of an effective amount of an agent which inhibits CD163 receptor activity in a target cells, wherein inhibition of CD163 activity is effective to impede HIV uptake into target monocytes. In another aspect of the invention, a screening method for identifying agents useful for the treatment of HIV infection is disclosed. An exemplary method entails incubating a population of monocytes expressing CD163 in the presence and absence of said test agent, b) contacting said monocytes with a compound that detectably labels said CD163, thereby determining CD163 expression levels in the presence or absence of said agent, agents which inhibit expression of CD163 in treated cells relative to untreated cells being useful for inhibiting HIV infection in said cell.
