There is employed an information processing system including: a photoacoustic image acquiring unit that acquires photoacoustic image data derived from photoacoustic waves generated by an object that is irradiated with light； a setting unit that sets a simulation condition； a reference image acquiring unit that acquires simulation image data being photoacoustic image data corresponding to the simulation condition set by the setting unit； and a display controlling unit that causes a photoacoustic image based on the photoacoustic image data and a reference image based on the simulation image data, to be displayed on a display unit.
