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Membrane-penetrating peptides to enhance transfection and compositions and methods for using same
专利权人:
Life Technologies Corporation
发明人:
De Mollerat Du Jeu, Xavier
申请号:
AU2014361806
公开号:
AU2014361806B2
申请日:
2014.12.12
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
The present invention is directed to non-naturally occurring peptides containing a membrane-penetrating amino acid sequence and further at least one polycationic moiety or peptide sequence. The peptides are suitable for use in delivery a cargo to the interior of a cell. Suitable cargo includes nucleic acid molecules (including DNA, RNA or PNA), polypeptides, or other biologically active molecules. The present invention is further directed to transfection complexes containing the non-naturally occurring peptides of the present invention in non-covalent association with at least one cationic lipid and a cargo to be delivered to the interior of a cell. The invention further relates to methods for the preparation and use of the non-naturally occurring peptides for the formation of transfection complexes and the delivery of a cargo to the interior of a cell in culture, an animal or a human. The invention also relates to compositions and kits useful for transfecting cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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