University of Pittsburgh- Of the Commonwealth System of Higher Education;Astute Medical, Inc.
发明人:
McPHERSON, Paul,KELLUM, John, A.
申请号：
EP17865610
公开号：
EP3532101A4
申请日:
2017.10.27
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The invention provides methods for the treatment of subjects having or at risk of having kidney injuries using antibodies that specifically bind Metalloproteinase inhibitor 2 (TIMP-2). Specifically, the methods can be used for the treatment of a subject having chronic kidney disease (CKD), acute kidney injury (AKI), or a subject having an existing diagnosis of one or more of congestive heart failure, preeclampsia, eclampsia, diabetes mellitus, hypertension, coronary artery disease, proteinuria, glomerular filtration below the normal range, cirrhosis, serum creatinine above the normal range, sepsis, or acute renal failure (ARP).
