VERFAHREN ZUR DIAGNOSE, VORBEUGUNG UND BEHANDLUNG VON KREBSGEHIRNMETASTASEN UND ARZNEIMITTELABGABESYSTEM ZUR ERMÖGLICHUNG DER PASSAGE DURCH DIE BLUT-HIRN-SCHRANKE
National Cancer Center; Ltd.;Gene Techno Science Co., Ltd.;Gene Techno Science Co.;Theoria Science Inc.
发明人:
OCHIYA, Takahiro,TOMINAGA, Naoomi
申请号：
EP15883072
公开号：
EP3263714A4
申请日:
2015.02.24
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
A purpose of the present invention is to provide a novel diagnosis and risk evaluation method for cancer brain metastasis and a novel treatment and prevention method therefor by clarifying the mechanism of blood-brain barrier (BBB) disruption in brain metastasis. Another purpose of the present invention is to provide a novel drug delivery system to the brain. Still another purpose of the present invention is to provide a medicine, composition and kit to be used in these methods. Therefore, the present invention relates to a method for diagnosing brain metastasis or evaluating the risk of the occurrence of brain metastasis, said method comprising determining miR-181c level in a specimen. Further, the present invention relates to a method for treating or preventing brain metastasis, said method comprising inhibiting the expression or activity of miR-181c in a cancer patient. Furthermore, the present invention relates to a method for improving permeability through BBB with the use of miR-181c or PDPK1 and a method for enabling a desired active ingredient to pass through BBB and reach inside the brain.
