This disclosure provides systems and methods for patient-specific identification and assessment of ocular disease risk factors and efficacy of various treatments. The systems and methods can include mathematically modeling an expected normal patient-specific value of one or more clinically observable properties using a patient-specific mathematical model that can be calibrated with patient-specific data. The expected normal patient-specific value can be compared with a measured patient-specific value. A greater difference between the expected and measured patient-specific values can correlate to greater ocular vasculature abnormalities.
