NISHIMURA, STEPHEN L.,LOU, JIANLONG,MARKS, JAMES D.,BARON, JODY L.,CHENG, YIFAN,WU, SHENPING,CORMIER, ANTHONY,TAKASAKA, NAOKI
申请号：
CA3036232
公开号：
CA3036232A1
申请日:
2017.09.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided is an antibody that specifically binds human a?ßß and blocks binding of TGFp peptide to a?ß8, wherein the antibody binds to the specificity determining loop (SDL) of human ß8. In some embodiments, the antibody further binds to one, two, or all three of the human av-head domain, the a1 helix of human ß8, or the a1 helix of human ß8. In some embodiments, the antibody is humanized or chimeric. In some embodiments, the antibody is linked to a detectable label. Also provided is a method of enhancing an immune response in a human individual, comprising administering a sufficient amount of the antibody to the individual, thereby enhancing an immune response. Also provided are pharmaceutical compositions comprising the anti-a?ßß antibodies or antigen-binding molecules thereof.
