A biopsy blade holder is provided that includes a substantially U-shaped body with a base, first and second opposing elongated members, first and second attachment structures and a restrictor. The elongated members extend from the base and diverge away from each other to first and second distal ends. A blade is inserted in the structures or fixedly attached near the distal ends. The restrictor is removably mounted to the exterior surfaces of the elongated members and adjusts and affixes the distance between the elongated members. Moving the restrictor towards the distal ends causes the blade to flex outwardly and adjusts the length of the blade edge that contacts the surface of a patients skin.