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AUTO-ANTIGENES ASSOCIES A LA SCLEROSE EN PLAQUES, ET UTILISATION DE CES DERNIERS EN THERAPIE ET DANS UN DIAGNOSTIC
专利权人:
TCER AB
发明人:
GRONLUND, HANS,BRONGE, MATTIAS
申请号:
CA3055373
公开号:
CA3055373A1
申请日:
2018.03.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
A tolerogenic composition for use in a method of treatment for multiple sclerosis (MS) in a MS patient exhibiting T-cell autoreactivity against an endogenous epitope corresponding to a T-cell epitope comprised in the amino-acid sequence of SEQ ID NO: 5, the composition comprising a therapeutic T-cell epitope comprising a sequence of 8 consecutive amino acid residues differing from a sub-sequence of SEQ ID NO: 5by 0-2residue substitutions, deletions and/or insertions, or the composition comprising a nucleic acid encoding said therapeutic T-cell epitope. A method for determining the degree of multiple sclerosis (MS) related autoimmunity in a test subject, comprising providing a test sample derived from the test subject comprising viable T-cells;quantitating antigen-specific activation of the T-cells of the test sample in vitro in response to a test antigen comprising a T-cell epitope, wherein said T-cell epitope is as the above therapeutic T-cell epitope above; and comparing the quantitated antigen-specific activation to a relevant reference to determine the degree of MS-related autoimmunity in the test subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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