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NEW CONJUGATES FOR DIRECTED DRUG DELIVERY
专利权人:
ВЕНУС РЕМЕДИЗ ЛИМИТЕД (IN)
发明人:
ЧАУДХАРИ Ману (IN)
申请号:
RU2013127786/15
公开号:
RU2013127786A
申请日:
2011.11.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A pharmaceutical composition based on a new drug delivery system for targeted delivery of at least one active drug, comprising a triple conjugate, wherein said triple conjugate comprises a therapeutically effective amount of a protein component capable of selectively binding to a specific target site in a cell / organ, polymer a component covalently bonded to said protein component; an active drug component comprising at least one the indicated active drug and covalently bonded either to said protein component or to said polymer component; wherein said active drug component and said protein component are chemically different from each other; where the indicated active drug is a non-biological object. 2. The pharmaceutical composition of claim 1, wherein said protein component, said polymer component, and said active drug component are linked to each other. The pharmaceutical composition of claim 1, wherein said triple conjugate is administered to a subject in need thereof as a single unit. The pharmaceutical composition of claim 1, wherein said polymer component is present in an amount ranging from 60% to 85% of the composition; where said protein component is present in an amount ranging from 6% to 12% of the composition; and where said active drug is present in an amount varying from 10% to 20% of the composition. 5. The pharmaceutical composition of claim 1, wherein the molecular weight of said triple conjugate is1. Фармацевтический состав на основе новой системы доставки лекарственного средства для направленной доставки по меньшей мере одного активного лекарственного средства, включающий тройной конъюгат, где указанный тройной конъюгат включает терапевтически эффективное количествобелкового компонента, способного селективно связываться с конкретным сайтом-мишенью в клетке/органе,полимерного компонента, ковалентно связанного с указанным белковым компонентом,компонента активного лекарственного средства, включающего по меньшей мере одно указанное активное лекарс
来源网站:
中国工程科技知识中心
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