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SPECIAL EXTRACT AND USE OF THE SAME FOR INHIBITION OF CYCLIC GUANOSINE MONOPPHOSPHERE DEGRADATION (CGMP)
专利权人:
FINZELBERG GMBH & CO. KG
发明人:
BJOERN FEISTEL,MATTHIAS-HEINRICH KREUTER
申请号:
BRPI0720292
公开号:
BRPI0720292A2
申请日:
2007.12.11
申请国别(地区):
BR
年份:
2014
代理人:
摘要:
Preparation of an extract (I) from a plant from the Turneraceae family, comprises extracting plant parts with an extracting agent, which contains water and an organic solvent (methanol, ethanol, propanol, isopropanol and/or acetone); concentrating the extract to a thick extract; and enriching lipophilic substances to the concentrate. An independent claim is included for the extract obtained by the above process. ACTIVITY : Vasotropic; Antidiabetic. MECHANISM OF ACTION : Human phosphodiesterase V (PDE-V) inhibitor. (I) (from T. aphrodisiaca) was tested for its PDE-V inhibitory activity by a tritium scintillation proximity assay. The results showed that the median inhibitory concentration of (I) was 10-15 mu g/ml.
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