COMPOSES ANTICANCEREUX DISTRIBUES DE MANIERE MITOCHONDRIALE

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专利权人:

NEUZIL, JIRI;RALPH, STEPHEN JOHN

发明人:

NEUZIL, JIRI,RALPH, STEPHEN JOHN

申请号：

CA2734208

公开号：

CA2734208C

申请日:

2009.03.16

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

This invention relates to anti-cancer compounds and to methods for treating orpreventing cancer. In one aspect theinvention concerns mitochondrially delivered pro-oxidant anti-cancer compoundsthat generate reactive oxygen species and induceapoptosis of cancerous cells. The delivery moiety can be a lipophilic cationand the pro-oxidant moiety can be a pro-oxidantvitamin E analogue, such as .alpha.-tocopheryl succinate, .alpha.-tocopherylmaleate, .alpha.-tocopheryl maleyl amide, or 2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)-chroman-6-yloxyacetic acid (.alpha.-tocopheryloxyacetic acid).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/