Invention herewith described refers to the serum for the therapy of women in postmenopausal period which is intended to compensate for estradiol, progesterone and occasionally testosterone in order to prevent complications by all organs and systems, reduced quality of life and early death. Topical application of creams and serums was aimed to affect only partly some of the skin components. The serum Sophia is the first serum containing estradiol, progesterone, tocopherol, vitamin C, in specified concentrations, in olive oil and Wolff substrate. This composition allows the impact on the etiologic factor that leads to skin aging and decay, and it is hypoestrogenism.Terapija žena u menopauzi ima za cilj da nadoknadi estradiol, progesteron i , povremeno testosteron u cilju sprečavanja pojave komplikacija od strane svih organa i sistema, smanjenja kvaliteta života i ranije smrti.Lokalna primena krema i seruma imala je za cilj da samo delom utiče na neku od komponenti kože.Serum Sofija je prvi koji u svom sastavu ima estradiol, progesteron, tokoferol,vitamin C, u određenim navedenim koncentracijama, u maslinovom ulju i Wolfovoj podlozi. Ovakav sastav omogućava uticaj na etiološki činilac koji dovodi do starenja i propadanja kože, a to je hipoestrogenija.
