BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS

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专利权人:

MERCK SHARP and DOHME CORP

发明人:

ALTMAN, Michael, D.,CASH, Brandon, D.,CHANG, Wonsuk,CUMMING, Jared, N.,HAIDLE, Andrew, M.,HENDERSON, Timothy, J.,JEWELL, James, P.,LARSEN, Matthew, A.,LIANG, Rui,LIM, Jongwon,LU, Min,OTTE, Ryan, D.,SI

申请号：

PH12019500712

公开号：

PH12019500712A1

申请日:

2019.04.01

申请国别(地区):

PH

年份:

2019

代理人:

摘要：

Compounds of general formula (la), compounds of general formula (la'), compounds of general formula (lb), compounds of general formula (lb'), compounds of general formula (I), compounds of general formula (?'), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.

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